Optimized reprocessing of documents using stored processor state

Variable Data Printing (VDP) allows customised versions of material such as advertising flyers to be readily produced. However, VDP is often extremely demanding of computing resources because, even when much of the material stays invariant from one document instance to the next, it is often simpler to re-evaluate the page completely rather than identifying just the portions that vary. In this paper we explore, in an XML/XSLT/SVG workflow and in an editing context, the reduction of the processing burden that can be realised by selectively reprocessing only the variant parts of the document. We introduce a method of partial re-evaluation that relies on re-engineering an existing XSLT parser to handle, at each XML tree node, both the storage and restoration of state for the underlying document processing framework. Quantitative results are presented for the magnitude of the speed-ups that can be achieved. We also consider how changes made through an appearance-based interactive editing scheme for VDP documents can be automatically reflected in the document view via optimised XSLT re-evaluation of sub-trees that are affected either by the changed script or by altered data

Reflowable documents composed from pre-rendered atomic components

Mobile eBook readers are now commonplace in today’s society, but their document layout algorithms remain basic, largely due to constraints imposed by short battery life. At present, with any eBook file format not based on PDF, the layout of the document, as it appears to the end user, is at the mercy of hidden reformatting and reflow algorithms interacting with the screen parameters of the device on which the document is rendered. Very little control is provided to the publisher or author, beyond some basic formatting options. This paper describes a method of producing well-typeset, scalable, document layouts by embedding several pre-rendered versions of a document within one file, thus enabling many computationally expensive steps (e.g. hyphenation and line-breaking) to be carried out at document compilation time, rather than at ‘view time’. This system has the advantage that end users are not constrained to a single, arbitrarily chosen view of the document, nor are they subjected to reading a poorly typeset version rendered on the fly. Instead, the device can choose a layout appropriate to its screen size and the end user’s choice of zoom level, and the author and publisher can have fine-grained control over all layouts

Tracking sub-page components in document workflows

Documents go through numerous transformations and intermediate formats as they are processed from abstract markup into final printable form. This notion of a document workflow is well established but it is common to find that ideas about document components, which might exist in the source code for the document, become completely lost within an amorphous, unstructured, page of PDF prior to being rendered. Given the importance of a component-based approach in Variable Data Printing (VDP) we have developed a collection of tools that allow information about the various transformations to be embedded at each stage in the workflow, together with a visualization tool that uses this embedded information to display the relationships between the various intermediate documents. In this paper, we demonstrate these tools in the context of an example document workflow but the techniques described are widely applicable and would be easily adaptable to other workflows and for use in teaching tools to illustrate document component and VDP concepts

Revisiting a summer vacation: digital restoration and typesetter forensics

In 1979 the Computing Science Research Center (‘Center 127’) at Bell Laboratories bought a Linotron 202 typesetter from the Mergenthaler company. This was a ‘third generation’ digital machine that used a CRT to image characters onto photographic paper. The intent was to use existing Linotype fonts and also to develop new ones to exploit the 202’s line-drawing capabilities. Use of the 202 was hindered by Mergenthaler’s refusal to reveal the inner structure and encoding mechanisms of the font files. The particular 202 was further dogged by extreme hardware and software unreliability. A memorandum describing the experience was written in early 1980 but was deemed to be too “sensitive” to release. The original troff input for the memorandum exists and now, more than 30 years later, the memorandum can be released. However, the only available record of its visual appearance was a poor-quality scanned photocopy of the original printed version. This paper details our efforts in rebuilding a faithful retypeset replica of the original memorandum, given that the Linotron 202 disappeared long ago, and that this episode at Bell Labs occurred 5 years before the dawn of PostScript (and later PDF) as de facto standards for digital document preservation. The paper concludes with some lessons for digital archiving policy drawn from this rebuilding exercise

Optimized reprocessing of documents using stored processor state

Variable Data Printing (VDP) allows customised versions of material such as advertising flyers to be readily produced. However, VDP is often extremely demanding of computing resources because, even when much of the material stays invariant from one document instance to the next, it is often simpler to re-evaluate the page completely rather than identifying just the portions that vary. In this paper we explore, in an XML/XSLT/SVG workflow and in an editing context, the reduction of the processing burden that can be realised by selectively reprocessing only the variant parts of the document. We introduce a method of partial re-evaluation that relies on re-engineering an existing XSLT parser to handle, at each XML tree node, both the storage and restoration of state for the underlying document processing framework. Quantitative results are presented for the magnitude of the speed-ups that can be achieved. We also consider how changes made through an appearance-based interactive editing scheme for VDP documents can be automatically reflected in the document view via optimised XSLT re-evaluation of sub-trees that are affected either by the changed script or by altered data

Generating summary documents for a variable-quality PDF document collection

The Cochrane Schizophrenia Group’s Register of studies details all aspects of the effects of treating people with schizophrenia. It has been gathered over the last 20 years and consists of around 20,000 documents, overwhelmingly in PDF. Document collections of this sort – on a given theme but gathered from a wide range of sources – will generally have huge variability in the quality of the PDF, particularly with respect to the key property of text searchability. Summarising the results from the best of these papers, to allow evidence-based health care decision making, has so far been done by manually creating a summary document, starting from a visual inspection of the relevant PDF file. This labour-intensive process has resulted, to date, in only 4,000 of the papers being summarised – with enormous duplication of effort and with many issues around the validity and reliability of the data extraction. This paper describes a pilot project to provide a computer-assisted framework in which any of the PDF documents could be searched for the occurrence of some 8,000 keywords and key phrases.Once keyword tagging has been completed the framework assists in the generation of a standard summary document, thereby greatly speeding up the production of these summaries. Early examples of the framework are described and its capabilities illustrated

Fiber Type Profile and its Relation to Wilks Coefficient in Both Male and Female Powerlifters

While powerlifters tend to display higher fast-twitch fiber content, it is unknown if this content predicts competitive performance via Wilks coefficient. Purpose: to 1) compare the myosin heavy chain (MHC) fiber type (FT) profiles between powerlifters and sedentary controls of both sexes, and 2) determine if fast-twitch fiber content predicts Wilks coefficient. Methods: Twelve actively competing powerlifters (PL; n=6M/6F; age=21±1.0y; 3.0±1.8y competing; 7.3±6.6 meets attended) and ten sedentary controls (CON; n=5M/5F; age=19.4±2.0y) underwent vastus lateralis muscle biopsies, with samples analyzed for MHC isoform content via mixed homogenate SDS-PAGE. Individual MHC isoform differences between group and sex were analyzed using a 3x2x2 (FT [MHC I, IIa, & IIx] x group [PL & CON] x sex [male & female]) ANOVA and MHC IIa content was compared to Wilks coefficient using Pearson correlation coefficient at pResults: Male PL MHC isoform distribution was 50±6% I, 45±6% IIa, and 5±11% IIx, vs 46±6% I, 53±6 IIa, and 0% IIx in PL females. Conversely, male CON MHC distribution was 33±5% I, 38±7% IIa, and 30±8% IIx, vs 35±9% I, 44±8% IIa, and 21±17% IIx in CON females. Analysis revealed a significant FT main effect (pConclusions:These results illustrate powerlifters have higher MHC I and IIa proportions, as well as lower MHC IIx content compared to sedentary controls. While overall limited by sample size, MHC IIa content does not appear to be a significant predictor of powerlifting Wilks coefficient, suggesting this characteristic alone does not define powerlifter skill variations

A Mixture of LBG Overdensities in the Fields of Three 6<z<76 < z < 7 Quasars: Implications for the Robustness of Photometric Selection

The most luminous quasars at $z > 6$ are suspected to be both highly clustered and reside in the most massive dark matter halos in the early Universe, making them prime targets to search for galaxy overdensities and/or protoclusters. We search for Lyman-break dropout-selected galaxies using HST WFC3/ACS broadband imaging in the fields of three $6 < z < 7$ quasars, as well as their simultaneously observed coordinated-parallel fields, and constrain their photometric redshifts using EAZY. One field, J0305-3150, shows a volume density 10$\times$ higher than the blank-field UV luminosity function (UVLF) at M$_{UV} < -20$, with tentative evidence of a 3$\sigma$ overdensity in its parallel field located 15 cMpc away. Another field, J2054-0005, shows an angular overdensity within 500 ckpc from the quasar but still consistent with UVLF predictions within 3$\sigma$, while the last field, J2348-3054, shows no enhancement. We discuss methods for reducing uncertainty in overdensity measurements when using photometric selection and show that we can robustly select LBGs consistent with being physically associated with the quasar, corroborated by existing JWST/NIRCam WFSS data in the J0305 field. Even accounting for incompleteness, the overdensities in J0305 and J2054 are higher for brighter galaxies at short angular separations, suggesting preferential enhancement of more massive galaxies in the immediate vicinity of the quasar. Finally, we compare the LBG population with previously-identified [CII] and mm-continuum companions; the LBG overdensities are not accompanied by an enhanced number of dusty galaxies, suggesting that the overdense quasar fields are not in the bursty star-forming phase sometimes seen in high-redshift protoclusters.Comment: 22 pages (main text), 12 figures, 10 tables, 2 appendices. Final version after addressing referee report, accepted to ApJ May 202

Human spermbots for patient-representative 3D ovarian cancer cell treatment

Cellular micromotors are attractive for locally delivering high concentrations of drug, and targeting hard-to-reach disease sites such as cervical cancer and early ovarian cancer lesions by non-invasive means. Spermatozoa are highly efficient micromotors perfectly adapted to traveling up the female reproductive system. Indeed, bovine sperm-based micromotors have shown potential to carry drugs toward gynecological cancers. However, due to major differences in the molecular make-up of bovine and human sperm, a key translational bottleneck for bringing this technology closer to the clinic is to transfer this concept to human material. Here, we successfully load human sperm with Doxorubicin (DOX) and perform treatment of 3D cervical cancer and patient-representative ovarian cancer cell cultures, resulting in strong anticancer cell effects. Additionally, we define the subcellular localization of the chemotherapeutic drug within human sperm, using high-resolution optical microscopy. We also assess drug effects on sperm motility and viability over time, employing sperm samples from healthy donors as well as assisted reproduction patients. Finally, we demonstrate guidance and release of human drug-loaded sperm onto cancer tissues using magnetic microcaps, and show the sperm microcap loaded with a second anticancer drug, camptothecin (CPT), which unlike DOX is not suitable for directly loading into sperm due to its hydrophobic nature. This co-drug delivery approach opens up novel targeted combinatorial drug therapies for future applications. © 2020 The Royal Society of Chemistry